I came across a blog post on ColourLovers (a bit outdated -- 2011) in which the author contemplates: is there a correlation between the color of a book’s cover, digital or physical, and its success within its genre?
Here were a few of his findings based on looking at the covers of books found on the New York Times Bestseller lists:
Bestselling Fiction: warm colors and metallics (see two examples on right)Bestselling Nonfiction: rich warm colors, non-metallic
Bestselling Children's Books: bright colors with dynamic lettering
Bestselling Harcover Graphic Novels: dark hues
So, I would assume that if a book within a specific genre, deviated from the "standard" colors found within that genre -- the odds of getting that book into the hands of its audience would suffer.