Book cover design by Thomas Keeley
http://thomaskeeley.net/index.html
A Growing Book by Eric Zhang.
The book is about the meaning of life and the idea is that you create life as you learn about its meaning. You can plant whatever plant you'd like on the left side. LED lights positioned under the "pot" help the plant grow and also create a night light that reflects the color of the plant. http://www.yankodesign.com/2007/05/08/growing-book-by-eric-zhang/
While doing some research, I found this guy, Robert The, who takes existing books and turns them into sculptures. It's not exactly book design, because you can't really read the books when he's done with them but I thought his work was really interesting. You can see some more of this work on his site http://www.bookdust.com.